May
31

Colocalization Experiment: GFP-vErbA and mCherry-rc6-TRα1

The mutant thyroid hormone receptor I have been studying, rc6, has a phenotype similar to that of a well characterized oncogenic protein: vErb-A. vErb-A is a highly mutated form of thyroid hormone receptor alpha that is linked to cancer formation. rc6 and vErb-A are both mutated forms of thyroid hormone receptor alpha. The mechanism by…
Read More

Apr
10

Characterization of a Mutant Thyroid Hormone Receptor Found in Renal Clear Cell Carcinoma

The Allison lab is investigating the localization of thyroid hormone receptor in human cells. Thyroid hormone is crucial for metabolic regulation. The thyroid gland releases thyroid hormone, which travels through the blood stream to target tissues. After entering cells, it binds to thyroid hormone receptor (TR) in the nucleus in order to affect gene expression.…
Read More