Apr
15

Investigating Intra-tumor stromal-cancer interactions on autophagy activity in renal carcinoma cells

Cancer cells communicate with their surrounding tumor microenvironment to initiate aberrant tumor growth and behaviors. Within this environment, stromal cells play a critical role in supporting carcinogenesis and metastasis. They may be doing so by misregulating autophagy, a metabolic process that degrades intracellular material in response to stress. I will investigate and build a data…
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Apr
14

Ethical Borders: Citizenship as a Partial Relationship

In our theoretical moral decisions, we usually uphold the value of true equality. In practicality, however, we frequently make moral decisions based on a partial consideration for the wants and needs of ourselves and those important to us. Many people feel that we should be allowed to refer to some degree of partiality– I should…
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Apr
13

Characterizing the Role of SPE-6 in Caenorhabditis elegans spermatogenesis

Meiosis, the process by which cells divide to produce cells used for reproduction, is incredibly complex and tightly regulated. Chromatin, which contains the genetic material crucial for forming a new organism, must be carefully arranged and rearranged throughout the four major stages of meiosis: prophase, metaphase, anaphase, and telophase. Chromatin organization during prophase is particularly…
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Apr
13

Abstract: Hydrogen-Deuterium Exchange and Fragmentation Studies of Peptides and Amino Acids

Mass spectrometry-based proteomics experiments, are broadly related to automated peptide sequencing. Mass spectrometry experimentation provides structure elucidation and give a relative understanding of gas-phase properties, fragmentation, and interactions between amino acid side groups, which are often neglected in automated peptide sequencing algorithms. This summer, I will performing H/D exchange on various amino acids and peptide…
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Apr
12

Abstract: Exploring the Evolutionary and Molecular Dynamics of Mixed Biofilms to Disrupt their Stability

Hello everyone! My name is Aparajita Sur and I will be doing my honors thesis on a computational biology topic.